Indole-3-Carbinol or I3C is used to enhance the rapid metabolism of estrogen and its compounds, thereby creating a balance in the estrogen levels from extreme low or high. Hence by regulating the estrogen level I3C actually works as a testosterone booster, though not directly but passively. The supplement is taken as an alternative to strong androgenic-anabolic steroids to accelerate the production of testosterone in the body. For detail knowledge, please visit The Health Magazine.
How does I3C work?
Indole-3-Carbinol goes by the chemical name of 1H-Indol-3-ylmethanol and is abundantly present in cruciferous vegetables like cabbage, broccoli, cauliflower, collard greens, kale and Brussels sprouts. Glucosinolates are predominantly present in cruciferous plants. A particular glucosinolate known as glucobrassicin when hydrolyzed or broken down by water molecules, it results in the formation of indole-3-carbinol. I3C exhibits a number of pathological aiding properties by acting as anti-carcinogenic, anti-inflammatory, antioxidant and hormone regulating agents. The compound has also shown to have anti-estrogenic effects, by balancing estrogen secretion in the body to an extent when it is not too low or too high. Therefore it supports healthy metabolism of estrogen hormone without disrupting the production pathway.
Aromatase enzyme is the key enzyme involved in the aromatization of androgens into estrogens. This enzyme plays a crucial role in the reaction pathway of steroidogenesis, which is the production of steroids from cholesterol and other complex steroid molecules. I3C possess the mechanism of blocking the activity of Aromatase by acting as an enzyme inhibitor compound. Due to normal process of aging, many men suffer from the low sperm quality and quantity, and the conversion of testosterone to estrogen at that time is highly unfavourable. Thus the inhibition of the Aromatase action by I3C can help men overcome infertility issues and boost their sexual drive.
Benefits of I3C:
Clinical experimentations on the efficacy of the supplement have been carried out to check its anti-cancerous properties and testosterone favouring characteristics. Indole-3-Carbinol induces the G1 stage arresting of mammalian reproductive cancerous cell cycle. This helps in the prevention of neoplastic cell growth as G1 phase of cell cycle is the most prolonged stage, featuring production of many enzymes essential for DNA replication in the S (synthetic) phase. By blocking the cycle at the initial point can reduce the chances of tumor susceptibility by decreasing aflatoxin-DNA binding, which is facilitated by I3C thereby demoting metastasis. I3C supplements can prove beneficial in the treatment of various types of cancer including prostrate and breast cancer.
By bringing down the levels of estrogen, I3C can promote elevated production of testosterone in the Leydig cells by inhibiting the direct action of aromatase. This can be used in the ailment of Gynecomastia (development of men breasts), sterility, decreased libido, extreme fatigue and erectile malfunction. When I3C supplements are consumed, the liver cells are triggered to readily metabolise estrogen compounds into 2-hydroxyestrone metabolites, thereby promoting estrogen breakdown. 2-hydroxyestrones are capable of inhibiting development of cancer cells and also pose a slow effect on the normal aging of the body. So these are ‘good estrogens’ as termed by researchers that protects your reproductive and somatic cells.
Although I3C has shown to have anti-estrogenic effects in various studies, its supplements can be safely used to bring down risks of cancer and improve libido by taking over strong androgenic-anabolic steroids in the market.